iLINCS
  • Signatures
  • Datasets
  • Genes
  • iLINCS Paper 2022
  • iLINCS Apps
    • GR calculator
    • GREIN
    • Signeta
    • History
    • Help
    • Support
    • API
  • What is iLINCS?
  • iLINCS Paper
  • Signatures
    • Search for a signature
    • Navigating signature landing page
    • Find signatures with pharmacological actions
  • Tutorial Videos
    • Workshops and seminars
    • Use Cases
    • Miscellaneous
  • Datasets
    • Search for LINCS Dataset
    • Navigating dataset landing page
    • Create a signature
    • Adjusting number of genes in a signature
    • Perform a multi-group analysis
  • Workflows
    • Analyze a drug signature and find other drugs with similar signatures
    • Analyze LINCS transcriptomic and proteomic datasets
    • Analyze genes against LINCS data
  • Tasks
  • Genes
    • Query a list of genes in LINCS dataset
  • Use Cases
    • Identify sets of drugs with similar transcriptional signatures
    • Identifying chemical perturbagens emulating genetic perturbation of MTOR protein
    • Mechanism of action analysis via connection to genetic perturbation signatures
    • Proteo-genomics analysis of cancer driver events in breast cancer
    • Reversing Estrogen Receptor (ER) signature profile
    • Reversing MTOR loss-of-function signature profile
    • What are my GENES doing in LINCS dataset?
  • F A Q
    • What is a signature
    • What is connectivity map
    • How signature connectivity analysis is performed in iLINCS
    • How perturbagen connectivity analysis is performed in iLINCS
    • Why is my signature correlation calculation different from iLINCS pre-calculated signature correlations?
    • How to construct signatures from iLINCS datasets
    • How to use iLINCS APIs in R
  • Datasets
    • LINCS
    • TCGA
    • GDS
  • Signature Libraries
    • LINCS consensus (CGS) gene knockdown signatures
    • Overview of precomputed signature libraries
    • Cancer Therapeutics Response Signatures
    • Connectivity Map signatures
    • Disease related signatures
    • DrugMatrix signatures
    • ENCODE transcription factor binding signatures
    • LINCS chemical perturbagen signatures
    • LINCS gene overexpression signatures
    • LINCS targeted proteomics signatures
    • Transcriptional signatures from EBI Expression Atlas
  • Integrated External Analysis Tools
    • PiNET
    • Morpheus heatmap
    • Enrichr
    • DAVID
    • ToppFun
    • GeneMANIA
    • Reactome
    • L1000CDS2
    • L1000FWD
    • X2K
  • Assays
    • GCP
    • RPPA
    • L1000
    • P100
    • RNA-seq

Search results for: tasks,signature

Adjusting number of genes in a signature (tasks)

"Create a signature" function generates a two-group sample differential expression signature within a selected dataset using top 100 differentially expressed genes between the groups as seen in the figure below. You may adjust the number of included genes for the signature creation. You can select a different set of differentially expressed genes based on different cutoff (fold change and p-values...

Create a signature (tasks)

An experiment may have a number of samples which are organized in different groups (sample subgroupings). One may wish to restrict analysis to only a subset of all the available samples for an experiment. If you are interested in the analysis of differentially expressed genes between two groups of samples, you may create a two-group sample differential expression signature by clicking "Create...


iLINCS (integrative LINCS) genomics data portal

BD2K-LINCSDATA COORDINATION AND INTEGRATION CENTER
a part of NIH LINCS Program

LINCS Tools

  • Data Portal
  • Enrichr
  • iLINCS
  • Life
  • piNET

Contact

Support