iLINCS
  • Signatures
  • Datasets
  • Genes
  • iLINCS Paper 2022
  • iLINCS Apps
    • GR calculator
    • GREIN
    • Signeta
    • History
    • Help
    • Support
    • API
  • Main articles
    • What is iLINCS?
    • iLINCS Paper
  • Tutorial Videos
    • Workshops and seminars
    • Use Cases
    • Miscellaneous
  • Workflows
    • Analyze a drug signature and find other drugs with similar signatures
    • Analyze LINCS transcriptomic and proteomic datasets
    • Analyze genes against LINCS data
  • Tasks
    • Signatures
      • Search for a signature
      • Navigating signature landing page
      • Find signatures with pharmacological actions
    • Datasets
      • Search for LINCS Dataset
      • Navigating dataset landing page
      • Create a signature
      • Adjusting number of genes in a signature
      • Perform a multi-group analysis
    • Genes
      • Query a list of genes in LINCS dataset
  • Use Cases
    • Identify sets of drugs with similar transcriptional signatures
    • Identifying chemical perturbagens emulating genetic perturbation of MTOR protein
    • Mechanism of action analysis via connection to genetic perturbation signatures
    • Proteo-genomics analysis of cancer driver events in breast cancer
    • Reversing Estrogen Receptor (ER) signature profile
    • Reversing MTOR loss-of-function signature profile
    • What are my GENES doing in LINCS dataset?
  • F A Q
    • What is a signature
    • What is connectivity map
    • How signature connectivity analysis is performed in iLINCS
    • How perturbagen connectivity analysis is performed in iLINCS
    • Why is my signature correlation calculation different from iLINCS pre-calculated signature correlations?
    • How to construct signatures from iLINCS datasets
    • How to use iLINCS APIs in R
  • Datasets
    • LINCS
    • TCGA
    • GDS
  • Signature Libraries
    • LINCS consensus (CGS) gene knockdown signatures
    • Overview of precomputed signature libraries
    • Cancer Therapeutics Response Signatures
    • Connectivity Map signatures
    • Disease related signatures
    • DrugMatrix signatures
    • ENCODE transcription factor binding signatures
    • LINCS chemical perturbagen signatures
    • LINCS gene overexpression signatures
    • LINCS targeted proteomics signatures
    • Transcriptional signatures from EBI Expression Atlas
  • Integrated External Analysis Tools
    • PiNET
    • Morpheus heatmap
    • Enrichr
    • DAVID
    • ToppFun
    • GeneMANIA
    • Reactome
    • L1000CDS2
    • L1000FWD
    • X2K
  • Assays
    • GCP
    • RPPA
    • L1000
    • P100
    • RNA-seq

Use Cases

Use case-1: Detecting and modulating mTOR pathway signaling.

Use case-2: Proteo-genomics analysis of cancer driver events in breast cancer.

Use case-3: Using iLINCS for analysis of transcriptional signature of COVID-19 infection.

Category: tutorial videos

Last updated on 25th Apr 2024


iLINCS (integrative LINCS) genomics data portal

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a part of NIH LINCS Program

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