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Tutorial-1: iLINCS landing page Navigation.
Tutorial-2: Analyze my genes against LINCS datasets.
Tutorial-3: Analyze LINCS transcriptomic and proteomic datasets.
Tutorial-4: Analyze a drug signature and find other drugs with similar signatures.
Tutorial-5: Datasets workflow.
Tutorial-6: Signature workflow.
Tutorial-7: Genes workflow.
Please visit:
iLINCS Workshop at LINCS Symposium Nov, 2020 and
Adverse Outcome Pathways with iLINCS - DEPHS Seminar for general workflows.
Alternatively you can go to iLINCS Video Portal for a complete set of tutorial videos.
Use case-1: Detecting and modulating mTOR pathway signaling.
Use case-2: Proteo-genomics analysis of cancer driver events in breast cancer.
Use case-3: Using iLINCS for analysis of transcriptional signature of COVID-19 infection.
1. One may be interested to see all the metadata available for a particular precomputed signature. Let's say we would like to see more information for "LINCSCP_131839" signature. Let's click on the signature title as shown in the figure below.
2. As seen in the figure below, clicking on the signature title, opens up a new window containing a landing page for that particular signature. Similar...
1. Search is a very important part of this portal given that the number of LINCS datasets and precomputed signatures is constantly growing. One is able to search for a LINCS dataset and/or precomputed signature of interest on iLINCS portal in a couple of ways. In the example below, we will search for a precomputed signatures for MCF7 cell line (the example of locating LINCS dataset of interest is...
1. One may also search for pre-computed signatures with pharmacological actions. To do this, let's click "Find Signatures with Pharmacological Actions" button on the bottom of Signatures pipeline landing page as shown below.
2. Clicking "Find Signatures with Pharmacological Actions" button will open a search field to input desired pharmacological actions as seen in the figure below. iLINCS will...
1. Search is a very important part of this portal given that the number of LINCS datasets and precomputed signatures is constantly growing. One is able to search for a LINCS dataset and/or precomputed signature of interest on iLINCS portal in a couple of ways. In the example below, we will search for LINCS dataset for MCF7 cell line (the example of locating precomputed signature of interest is...
In the "Signatures" pipeline, you may explore, analyze and visualize over 200,000 pre-computed signatures (i.e. list of "scores" (activity levels) for a list of genes or for all genes in the genome "genome-wide signatures"). One would land on the Signatures landing page by clicking "Signatures" on the iLINCS portal header.
As shown in the figure above, there are 9 pre-computed signature libraries...
GR calculator
GREIN
Signeta